Differential Mycobacterium bovis BCG Vaccine-Derived Efficacy in C3Heb/FeJ and C3H/HeOuJ Mice Exposed to a Clinical Strain of Mycobacterium tuberculosis
نویسندگان
چکیده
منابع مشابه
Field evaluation of the efficacy of Mycobacterium bovis BCG vaccine against tuberculosis in goats
BACKGROUND Control of animal tuberculosis (TB) through vaccination has emerged as a long-term strategy to complement test and slaughter control strategy. A pilot trial under field conditions was conducted in a goat herd with high TB prevalence to assess the efficacy of the Mycobacterium bovis BCG vaccine. RESULTS Twenty-three goat kids vaccinated with BCG and other 22 unvaccinated control kid...
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Mycobacterium bovis BCG is one of the most commonly administered vaccines. Complications, including disseminated BCG disease, are rare but increasingly reported in immunodeficient children. There is growing recognition of the importance of differences between BCG vaccine strains. We determined the susceptibilities of five genetically distinct BCG vaccine strains to 12 antituberculous drugs.
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Mice that consumed a single dose of 10(7) lipid-encapsulated Mycobacterium bovis BCG bacilli showed significant pulmonary and systemic protection against aerosol challenge with M. tuberculosis H37Rv. As an extension of previous challenge studies with virulent strains of M. bovis, this report describes a reduction in M. tuberculosis infection in mice vaccinated orally with lipid-encapsulated BCG...
متن کاملA double recombinant Mycobacterium bovis BCG strain for screening
12 Affiliations: 13 14 Vandana Singh 15 Senior Project Fellow 16 Division of Microbiology 17 CSIR-Central Drug research Institute 18 Lucknow, 226031, INDIA, E. mail: [email protected] 19 20 Rajesh Kumar Biswas 21 Senior Research Fellow 22 Division of Microbiology 23 CSIR-Central Drug research Institute 24 Lucknow, 226031, INDIA, E. mail: [email protected] 25 26 27 28 29 Corresponden...
متن کاملSeparation of Mycobacterium bovis BCG from Mycobacterium tuberculosis and Mycobacterium bovis by using high-performance liquid chromatography of mycolic acids.
Profile analysis of mycolic acid ester patterns of Mycobacterium tuberculosis, Mycobacterium bovis, and Mycobacterium bovis bacillus Calmette-Gúerin (BCG) using high-performance liquid chromatography indicated that separation of BCG from M. tuberculosis and M. bovis by elution and relative retention times is possible. Mycolic acid patterns of BCG eluted from the column 0.5 min before M. tubercu...
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ژورنال
عنوان ژورنال: Clinical and Vaccine Immunology
سال: 2014
ISSN: 1556-6811,1556-679X
DOI: 10.1128/cvi.00466-14